Hello Charles, thank you for posting in the Microsoft Q&A community.
When a motherboard is replaced on an OEM device, the OEM Activation 3.0 (OA 3.0) product key stored in the new motherboard's UEFI/BIOS firmware differs from the key originally installed on the Hard Drive Assembly (HDA). Windows activation and setup prioritize the embedded firmware key. Because the hardware identifier has changed, Windows detects a mismatch between the Software Licensing store on the hard drive and the ACPI MSDM table on the new motherboard, leading to an activation or installation failure.
Depending on what you are trying to achieve, here are the most effective approaches to resolve:
Open an elevated Command Prompt or PowerShell (as Administrator) and execute the following command to retrieve the new OA 3.0 key embedded in the BIOS:
(Get-WmiObject -query 'select * from SoftwareLicensingService').OA3xOriginalProductKey
Once you retrieve the 25-character product key, install it into the current Windows image using the Software Licensing Management Tool by running:
slmgr.vbs /ipk <Your-25-Character-Product-Key>
After successfully installing the key, force the activation to Microsoft's licensing servers by running:
slmgr.vbs /ato
I will follow up on this thread to ensure that you regain access to your licenses. If this helps, please consider clicking "Accept answers" to help others with the same issues.